Evaluation of an applicator developed for the treatment of superficial lesions by high dose rate brachytherapy
DOI:
https://doi.org/10.29384/rbfm.2024.v18.19849001763Keywords:
dosimetry, radiochromic films, brachytherapy, skin lesionsAbstract
Brachytherapy is a form of radiotherapy that uses radioactive sources positioned inside tumors or deposited on the skin. The quality and dosimetry of applicators guiding the radiation to the tumor are crucial. This study aims to evaluate the dosimetry and attenuation properties of an applicator developed for the treatment of skin lesions. Comprising 15 spheres of synthetic material, the applicator was designed to be traversed by an Ir-192 source from an HDR device. Dosimetric evaluation was carried out using Gafchromic™ EBT3 radiochromic films, a solid water phantom Gammex® 457, and the applicator. The software OncentraBrachy 3D version 4.3 was employed for the planning of the desired dose distribution. Film readings were performed using an Epson Expression® 10000XL scanner, with ImageJ and Origin® software for data acquisition and processing. Irradiations were conducted with a dose of 500 cGy at the applicator's surface, as prescribed for the treatment of skin lesions. The material of the spheres, with a density close to that of water, was identified. The distribution of the applied dose was assessed over an active length of 10 cm. It was observed that the dose value at the center of the applicator corresponded to the prescribed dose of 500 cGy, indicating that the applicator does not interfere with the prescribed dose for superficial lesions.
Downloads
References
Instituto Nacional de Câncer (INCA). Estimativa 2023: Incidência de Câncer no Brasil. 2nd ed. Rio de Janeiro, Brasil: Instituto Nacional de Câncer José Alencar Gomes da Silva, Coordenação de Prevenção e Vigilância; 2023.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68(6):394-424.
McCune JS. Rapid advances in immunotherapy to treat cancer. Clinical Pharmacology & Therapeutics. 2018;103(4):540-4.
Mayer R, Schmid MP, Wanschitz J, Bettermann K, Haug AR, Geinitz H, et al. MRI-Guided Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) during Routine Clinical Care: Comparison of Plan Quality and Clinical Outcomes with Standard Planning. Cancers. 2021;13:410.
Skowronek J. Brachytherapy in the treatment of skin cancer: an overview. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2015;32(5):362.
Daurade M, Breton P, Rouard N, Lorchel F, Ibrahim B, Sigaux N. Efficacy of Surgical Excision and Brachytherapy in the Treatment of Keloids: A Retrospective Cohort Study. Advances in Skin & Wound Care. 2020;33(11):1-6.
Szewczyk MP, Pazdrowski J, Dańczak-Pazdrowska A, Golusiński P, Majchrzak E, Łuczewski Ł, et al. Analysis of selected recurrence risk factors after treatment of head and neck basal cell carcinoma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2014;31(3):146.
Salvajoli JV, Souhami L, Faria SL. Radioterapia em Oncologia. 2nd ed. São Paulo: Atheneu; 2013.
Bijlard E, Kouwenberg C, Timman R, Hovius S, van Busschbach J, Mureau M. Burden of keloid disease: a cross-sectional health-related quality of life assessment. Acta dermato-venereologica. 2017;97(2):225-9.
Hoang D, Reznik R, Orgel M, Li Q, Mirhadi A, Kulber DA. Surgical excision and adjuvant brachytherapy vs external beam radiation for the effective treatment of keloids: 10-year institutional retrospective analysis. Aesthetic surgery journal. 2017;37(2):212-25.
Viegas CCB, Lopes RT, Batista DVS, Rosa LAR. In vivo measurements in radiotherapy patients for head and neck cancer treatment; Medidas in vivo em pacientes submetidos a radioterapia para tratamento de câncer de cabeca e pescoço. 2002.
Liu HW, Gräfe J, Khan R, Olivotto I, Barajas J. Role of in vivo dosimetry with radiochromic films for dose verification during cutaneous radiation therapy. Radiation Oncology. 2015;10(1):1-7.
Butson MJ, Cheung T, Peter K. Radiochromic film dosimetry in water phantoms. Physics in Medicine & Biology. 2001;46(1):N27.
Devic S, Tomic N, Lewis D. Reference radiochromic film dosimetry: review of technical aspects. Physica Medica. 2016;32(4):541-56.
Santos T, Ventura T, do Carmo Lopes M. A review on radiochromic film dosimetry for dose verification in high energy photon beams. Radiation Physics and Chemistry. 2021;179:109217.
Nolasco AV. Métodos de dosimetria de superfícies aplicados ao controle de qualidade e investigação de dose na pele em tratamentos de Radioterapia. Brasil: Universidade Federal de Minas Gerais; 2017.
Devic S, Seuntjens J, Sham E, Podgorsak EB, Schmidtlein CR, Kirov AS, et al. Precise radiochromic film dosimetry using a flat-bed document scanner. Medical physics. 2005;32(7Part1):2245-53.
Tagiling N, Ab Rashid R, Azhan SNA, Dollah N, Geso M, Rahman WN. Effect of scanning parameters on dose-response of radiochromic films irradiated with photon and electron beams. Heliyon. 2018;4(10): e00864.
Calatayud JP, Ballester F, Das RK, De Werd LA, Ibbott GS, Meigooni AS, Ouhib Z, Rivard MJ, Sloboda RS, Williamson JF. Dose calculation for photon-emitting brachytherapy sources with average energy higher than 50 keV: Full Report of the AAPM and ESTRO Working Group 2012. Available as AAPM Report nº. 229.
Aldelaijan S, Bekerat H, Buzurovic I, Devlin P, DeBlois F, Seuntjens J, et al. Dose comparison between TG-43–based calculations and radiochromic film measurements of the Freiburg flap applicator used for high-dose-rate brachytherapy treatments of skin lesions. Brachytherapy. 2017;16(5):1065-72.
Calatayud JP, Granero D, Ballester F, Puchades V, Casal E et al. A Dosimetric Study of Leipzig Applicators.Int. J. Radiation Oncology Biol. Phys., 2005; Vol. 62, No. 2, pp. 579–584. doi:10.1016/j.ijrobp.2005.02.028
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Juan Carlos Chrisostomo Lamônica
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The submission of original articles to the Brazilian Journal of Medical Physics implies the transfer, by the authors, of the rights of print and digital publication. Copyright for published articles remains with the author, with journal rights on first publication. Authors may only use the same results in other publications by clearly indicating this journal as the original publisher. As we are an open access journal, free use of articles in educational, scientific, non-commercial applications is allowed, as long as the source is cited.
The Brazilian Journal of Medical Physics is under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
